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KMID : 0388220100170040422
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Journal of the Korean Rheumatism Association
2010 Volume.17 No. 4 p.422 ~ p.425
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A Case of Bullous Pemphigoid Arising after Infliximab Therapy in a Patient with Rheumatoid Arthritis
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Park Seong-Oh
Lee Ji-Hyun
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Abstract
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Bullous pemphigoid is an autoimmune, subepidermal blistering disease commonly seen in the elderly. It is known as autoimmune bullous dermatoses with an estimated prevalence of 1 in 40,000 and shows no gender or racial predilection. It has an autoimmune nature with immunoglobulin (Ig) G and/or C3 complement targeting hemidesmosomal antigens located in the epidermal basement membrane zone. Drug-induced pemphigoid, although rare, can occur in patients taking penicillamine, furosemide, captopril, penicillin, or sulfasalazine, but infliximab- induced pemphigoid has not been reported. We experienced a case of infliximab-induced pemphigoid in 54-year-old woman with a 17-year history of rheumatoid arthritis.
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KEYWORD
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Infliximab, Bullous pemphigoid, Rheumatoid arthritis
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